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Studies show that estrogen therapy during menopause can attenuate visceral fat gain by as much as 60%, improve insulin sensitivity, and even help increase lean muscle mass

Compared with unexposed pregnancies, the GLP-1 RA-exposed group had a higher risk for excess gestational weight gain (risk ratio, 1.32), greater mean birth weight percentile (58.4 versus 54.8 percent), and a higher risk for preterm delivery, gestational diabetes, and hypertensive disorders of pregnancy (risk ratios, 1.34, 1.30, and 1.29, respectively)

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As adipose tissue decreases, alterations in sex hormone metabolism, insulin sensitivity, and inflammatory markers occur