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Contaminant Category 1: Bacterial Endotoxins (Lipopolysaccharide) Gram-negative bacterial contamination during peptide synthesis produces lipopolysaccharide (LPS), a potent pyrogen
Class NNMT Inhibitor (Nicotinamide N-methyltransferase) Molecular Weight 193.2 Da (small molecule) Half-life Under investigation Purity 98% (HPLC) Form Powder Storage 20C, dry, protected from moisture Reconstitution DMSO or sterile water (partial solubility) Mechanism of action 5-Amino-1-methylquinolinium (5-Amino-1MQ) is a competitive inhibitor of NNMT an enzyme overexpressed in adipose tissue in obesity that converts nicotinamide to 1-methylnicotinamide while consuming SAM (S-adenosyl methionine)
The peptide-bound and free-metal conditions should be distinguished experimentally
BMJ Open 7:e013351
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