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In a series of fluorescence microscopy and biochemical studies, Epitalon was shown to enter the nuclei of human HeLa cells and bind selectively to DNA regions rich in CAG and ATTTC repeats, sequences that are common within promoter regions of the telomerase gene [1,32,33]
The co-regulation of the gut microbiome and host genes might play essential roles in metformin gastrointestinal intolerance
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