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102 In an in vitro study with cultured ADSCs treated with HCCs and linear or cross-linked HA, HCCs improved adipogenic differentiation and viability as evidenced by a greater increase in LPL expression at Day 14 (40-fold compared to baseline), greater adiponectin immunofluorescence staining (Day 14), and improved Oil Red O staining (Day 14)

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487,488 Long-term follow-up studies from the Epidemiology of Diabetes Interventions and Complications (EDIC) research have confirmed these benefits