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Wrap the ice pack in a cloth or towel to prevent freezing damage

doi: 10.1101/gad.177857.111 235 CoskunTBinaHASchneiderMADunbarJDHuCCChenYet al

Caloric Restriction In the heart, CR can attenuate age-related changes that occurred in the myocardium, i.e., hypertrophy, fibrosis, and apoptosis (Weiss and Fontana, 2011), and can preserve or improve diastolic function