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The study contributed to a developing preclinical literature suggesting AOD-9604 may have applications in joint and cartilage research distinct from its original metabolic indication

Aging reduces NAD+ synthesis pathways while increasing consumption by enzymes like CD38 and PARPs, activated by inflammation and damage.[13][15] CD38, an immune-related enzyme, ramps up with age, breaking down NAD+ precursors

Critical Functions of B12 in the Body Vitamin B12 helps with energy production , nerve function , and making red blood cells

Pernicious AnemiaPernicious anemia is a blood disorder in which the body does not make enough red blood cells due to a lack of vitamin B12 in the blood