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Their nonspecific distribution also causes toxicity in organs such as liver, kidneys, lungs, and heart (van Erven and Schalij 2010)
Large DE, Abdelmessih RG, Fink EA, Auguste DT
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Tau oligomers bind to cardiolipin, and this binding leads to the creation of membrane pores, causing mitochondrial swelling, cytochrome c release, and a reduction in membrane potential ( Figure 5 illustrates schematically the processes that eventually lead to Alzheimers disease, where the major players are Abeta, phosphorylated tau, and cardiolipin
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