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Here is an honest look at where the science stands as of early 2026: Animal studies are promising

Patients with severe insulin resistance exist a the top upper left hand corner of this chart

The activities of DHAR and GR were also found to be increased under heat stress in temperature sensitive orchid Phalaenopsis (Ali et al., Similar to heat stress, low temperature stress also induces H 2 O 2 production in cells (Suzuki and Mittler, 2006) and is known to up-regulate transcripts, protein level and activities of different ROS-scavenging enzymes (Prasad et al., 1994

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