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Longitudinal studies show that a baseline CNFL threshold of 14.1 mm/mm 2 predicts DN onset within 6 years with 67% sensitivity and 71% specificity [46]
GLP-1R reduces oxidative damage accumulation by modulating autophagy-related proteins and scavenging damaged mitochondria while increasing superoxide dismutase (SOD) and glutathione peroxidase activities, reducing the generation of lipid peroxidation products, inhibiting the NF-B signaling pathway, and decreasing proinflammatory factor expression to reduce neuroinflammation (Ma et al., 2018
An excisional or incisional biopsy is indicated for definitive diagnosis
A growing wave of research is showing the medical potential of GLP-1 therapies beyond weight loss
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