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However, SGLT2 inhibition reduces volume overload not only by intravascular volume depletion but also by reduction of interstitial fluid volume, and the latter effect can even exceed the contraction of the intravascular volume mediated by loop diuretics or thiazide analogues [23]
Dihexa has also been patented for potential use in treating Alzheimers and Parkinsons disease, though human clinical evidence remains in early stages
Hmgb1-mediated neuroinflammatory responses in brain injuries: potential mechanisms and therapeutic opportunities
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