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The biological effects of crotonylation ultimately depend on reader proteins that can specifically recognize this modification
Thus, it is possible that GSH depletion in MYCdriven liver tumors results from multiple mechanisms, including decreased synthesis, elevated Sglutathionylation, and elevated gammaglutamyl cycling, although we did not find strong metabolic support for the latter two mechanisms
DPP-4 is a serine protease that is expressed on the surface of endothelial cells, T-lymphocytes & in a circulating form
When delivered nasally, both peptides can bypass digestive breakdown and enter circulation more directly, supporting consistent peptide availability throughout the day
