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Mechanism of retatrutide receptor interaction According to the results of preclinical and clinical studies, retatrutide acts as a triple agonist of the GLP-1, GIP and GCGR receptors, influencing the regulation of appetite, glucose metabolism and energy expenditure

Therefore, besides citrate-derived acetyl-CoA by nuclear ATP-citrate lyase 68 , the carnitine-mediated supply of acetyl groups is also an important source of acetyl-CoA for nuclear histone acetylation

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