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doi: 10.1172/JCI39335 115 RettewJAHuet-HudsonYMMarriottI

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Conclusion: Study reveals that when metformin is administered before to enteral glucose rather than concurrently with it, it lowers blood glucose levels more effectively in type 2 diabetes that is well-controlled on metformin and is linked to a higher GLP-1 response

That single fractionation study is the proof point researchers still cite more than fifty years later as the origin of the entire copper-peptide research field: a compound identified almost by accident in a liver-aging comparison went on to become one of the most studied metallopeptides in dermal and regenerative research