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The beneficial effects of GLP-1 receptor activation on glycemia occur through several mechanisms: GLP-1 stimulates glucose-dependent insulin secretion from pancreatic -cells, suppresses inappropriately elevated glucagon secretion from pancreatic -cells, delays gastric emptying, and induces satiety via a direct action in the central nervous system
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Patients taking medications that can cause hypoglycaemia (such as when GLP-1 therapy is combined with insulin or sulfonylureas) should follow DVLA 'Assessing fitness to drive' guidance, including appropriate glucose monitoring before and during driving
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