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10.4269/ajtmh.2011.10-0409 115 SundarS.SinhaP
Among GLP-1 medications specifically, semaglutide has one of the longest half-lives: Exenatide (Byetta): approximately 2.4 hours, requires twice-daily injections Liraglutide (Saxenda, Victoza): approximately 13 hours, requires once-daily injections Dulaglutide (Trulicity): approximately 5 days, requires once-weekly injections Semaglutide (Ozempic, Wegovy): approximately 7 days, requires once-weekly injections Tirzepatide (Mounjaro, Zepbound): approximately 5 days, requires once-weekly injections Semaglutides seven-day half-life ties it with dulaglutide for the longest among currently approved GLP-1 medications
After 4 weeks, the semaglutide dose was increased to 0.5 mg/week
About 45% of the 2,339 patients in the trial lost 30% or more
