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Not dramatically different, not overnight different, just lighter somehow

PPIs exert their effect by irreversibly binding the H+/K+ ATPase proton pump on parietal cells

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Analysts at the time were bullish about these findings, with BMO Capital Markets noting that orforglipron achieved injectable like efficacy. Study participants also lost 7.9% body weight after orforglipron treatment, as compared with 1.6% in placebo