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Oxidative damage has been linked to high levels of eryptosis through an increase in the intracellular free Ca 2+ concentration, as evidenced by in vitro studies [24, 134, 300, 301] in patients intoxicated with lead [302], and in diabetic patients with chronic renal damage [303]
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Thus, each of such arising subpopulations is clonally derived from a single founder progenitor cell, thereby representing a genetic clone of this founder
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