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The most commonly reported side effects were mild and included headache, minor gastrointestinal disturbances (flatulence, mild diarrhea at high doses), upper respiratory symptoms, and mild injection site reactions
First, a bacterial reverse mutation test (Ames test) assessed AOD9604s mutagenic potential using four histidine-dependent auxotrophic mutants of Salmonella typhimurium (TA1535, TA1537, TA98, TA100) and one tryptophan-dependent auxotrophic mutant of Escherichia coli (WP2 uvrA), using both plate incorporation and pre-incubation methods at doses of 0, 1.6, 8, 40, 200, 1,000, and 2,000 g AOD9604/plate
Cells with adequate NAD+ respond more effectively to insulin, improving glucose uptake and reducing the likelihood of insulin resistance developing or worsening
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