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Expert Review of Endocrinology & Metabolism, 2025) The Fertility Paradox Worth Discussing With Your Provider For patients not actively trying to conceive, restored ovulation can be an unexpected and clinically significant side effect of treatment meaning contraception planning should be part of the conversation when starting GLP-1 therapy for PCOS, not an afterthought

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demonstrated that IL-6 deficiency attenuated the development of SIM through upregulation of the peroxisome proliferator-activated coactivator-1 and inhibition of mitochondrial ROS production (16)

Ursini F, Maiorino M, Valente M, Ferri L, Gregolin C