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Heres a quick guide Ive been working on for teaching and portfolio use: Indications & Concentrations - Anaphylaxis (IM): 1:1000 (1 mg/mL) - Cardiac Arrest (IV/IO): 1:10,000 (0.1 mg/mL) - Severe Asthma (SC/IM): 1:1000 (1 mg/mL) - Local Anesthesia adjunct: 1:100,000 1:200,000 - Microsurgery/Ophthalmic: 1:400,000 Preparation (Step-by-Step) - 1:10,000 1 mL of 1:1000 + 9 mL NS - 1:100,000 1 mL of 1:1000 + 99 mL NS - 1:200,000 0.5 mL of 1:1000 + 99.5 mL NS - 1:400,000 0.25 mL of 1:1000 + 99.75 mL NS Clinical Pearls Never give IV bolus of 1:1000 IM route is safest for anaphylaxis Always label syringes clearly Monitor ECG, BP, SpO when IV is used Avoid end-arterial infiltration with local anesthesia Takeaway: Adrenaline saves lives-but precision in dilution and administration is what makes it safe

However, they have separate FDA approvals for different conditions

27 marzo

as well as potential indications like Psoriatic arthritis and Type 1 diabetes mellitus in the seven major markets, i.e., the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan