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Why Immunogenicity Matters for GLP-1 Peptide Drugs Peptide-based therapeutics inherently carry a higher immunogenic risk than small molecules due to their size, sequence complexity, and structural similarity to endogenous proteins
Its triple-agonist activity and once-weekly schedule distinguish it from older incretin drugs, requiring carefully planned titration to balance efficacy and safety
PGC-1alpha induction Activated factors increase PPARGC1A (PGC-1alpha) gene transcription in myocyte nuclei
A limitation with the use of GLUTag cells, as well as other models for epithelial cells, is that the cells have lost their polarization, which may affect the amino acid sensing mechanisms, as different amino acid transporters are situated on the apical compared to the basolateral membrane [28]
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