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It is a large, predominantly nuclear protein (~95 kDa in humans) that contains a C-terminal functional module comprising an L7Ae-type RNA-binding domain (RBD, also found in ribosomal protein L7Ae and in the core of box C/D and H/ACA snoRNPs), flanked by a Sec incorporation domain (SID) that mediates its interaction with EEFSEC [51, 52]

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Symptoms include itching, skin rashes, swelling, or difficulty breathing

Design, synthesis and anti-diabetic activity of triazolotriazine derivatives as dipeptidyl peptidase-4 (DPP-4) inhibitors