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Very high baseline A1C and long-standing diabetes Pre-existing diabetic retinopathy or macular edema Concurrent insulin therapy Large and rapid A1C reductions over a short period Additional vascular risks such as high blood pressure, high cholesterol, kidney disease, or sleep apnea Improving glucose control remains important for long-term eye health

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Effects of Glucagon-Like Peptide-1 Receptor Agonists on Gut Microbiota in Dehydroepiandrosterone-Induced Polycystic Ovary Syndrome Mice: Compared Evaluation of Liraglutide and Semaglutide Intervention

To support better subcutaneous administration practices, rotate injection sites regularly between the abdomen, thighs, and upper arms