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Furthermore, Gclc -deficient FoB have a block in the mitochondrial electron transport chain (ETC) due to diminished complex I and II activity and thereby accumulate the tricarboxylic acid cycle metabolite succinate

Mechanisms : Its neuroprotective effects may stem from reducing oxidative stress, modulating inflammatory cytokines, and promoting angiogenesis to repair damaged brain tissue

This happens through the aptly named "glutathione-ascorbic acid cycle." In another observational study, individuals with lower levels of vitamin C also had insufficient levels of glutathione, hinting at the symbiotic connection between the two

Reasonable approaches include: Stabilization approach: Wait until Ozempic dose is titrated to maintenance level and side effects have stabilized, typically 4-8 weeks