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Myeloproliferative neoplasms (such as polycythaemia vera or chronic myeloid leukaemia) and acute leukaemias can increase B12-binding proteins (transcobalamins), raising total serum B12
Nature 608 , 778783 (2022)
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The STEP trials showed continued weight loss improvement at higher doses, with the dose-response relationship remaining positive through 2.4 mg
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