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demonstrated that antioxidant vitamin therapy, including vitamin A at 417 U/kg, ameliorated myocardial apoptotic activity and reduced inflammatory signaling pathways associated with septic pathophysiology (Carlson et al., 2006)
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Therefore, considering the overlapping yet distinct roles of insulin and IGF-1 in the brain, disruptions in their signaling pathways due to IR may contribute to the neurobiological mechanisms underlying depression in individuals with T2DM
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