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In the natural aging + FOXO4-DRI group, mice received intraperitoneal injections of FOXO4-DRI (5 mg/kg, MCE, HY-P4157) every 2 days during the same period, followed by tissue collection
In multiple animal models of retinal degeneration, TF supplementation lowered retinal iron levels, reduced oxidative stress and inflammation, and preserved photoreceptor loss, leading to both anatomical and functional benefits [28,29,30,31,32]
The standard Melanotan 2 dosage is 0.25 mg daily for a 7 to 14 day loading phase, increasing to 0.5 mg if tolerated, followed by 0.5 mg once or twice weekly for maintenance
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