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Phosphono analogues of glutathione as new inhibitors of glutathione S-transferases
Mechanistically, CB-839 elevates the levels of intracellular ROS, enhances the movement of Nrf2 into the nucleus, leading to an increase in uridine phosphorylase 1 (UPP1) mRNA expression
doi: 10.1080/13813450701661198 89 FraternaleA.BrunduS.MagnaniM
Practical Takeaways There is some limited evidence that support CJC-1295s mechanism in modulating the GH/IGF-1 axis
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