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Choi emphasizes that thinking about or reverting to how your body used to function before taking one of these medicines can feel demoralizing or like a step back, especially if it brought positive changes to your life
Harkavyi A, Abuirmeileh A, Lever R, Kingsbury AE, Biggs CS, Whitton PS
With the approval of the FDA, weight loss medications like semaglutide now offer a medically-supported solution to assist patients in their weight management journey
Retatrutide vs Tirzepatide: Next-Generation Weight Loss Medications Last Updated: February 2026 11 min read Key Takeaways Retatrutide is an investigational triple hormone agonist (GLP-1, GIP, and glucagon) showing 24% average weight loss in trials, while tirzepatide is FDA-approved with proven 21% weight loss
