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Limitations Direct trial evidence is in HIV-associated populations
158,161,164,165 However, activating multiple receptors may lead to more complex side effects, and in some experiments, dual and triple agonists have indeed shown more severe side effects
Most patients experience significant weight regain after stopping GLP-1 medications, with clinical trials showing regain of substantial weight within the first year
It is subsequently released at synapses in the brain, exerting short-term effects on postsynaptic excitability and longer-term effects on synaptic strength and neural plasticity
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