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These include transketolase-like 1 and 2 proteins, TKTL1 and TKTL2, as well as the ubiquitous (PDHA1) and testis-specific (PDHA2) isoenzymes of the -subunit of PDH (PDHA) (Figure 1B)
They can cause discomfort, become disfiguring and in rarer cases become life threatening
Originally developed to manage type 2 diabetes, these medications mimic the GLP-1 hormone, which plays a key role in regulating appetite, slowing gastric emptying, and enhancing feelings of fullness
Supporting that idea, one preclinical study tested SNAC-based oral delivery of a dual GIP/GLP-1 peptidesimilar in class to tirzepatide, though not tirzepatide itselfand found that bioavailability remained low and highly variable in animal models
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