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272 A similar effect of circHIPK3 on hyperglycemia and IR has been observed by sponging miR-192-5p and increasing FOXO1 expression 273

In some studies, the Thr metabolism-related product -aminobutyric acid (AABA) has been shown to suppress the expression of pro-inflammatory macrophage-related genes and to jointly restrain inflammatory responses through metabolic reprogramming and EZH2-dependent epigenetic regulation, suggesting that the effects of amino acid metabolism on macrophage function may also extend to the level of metabolism-epigenetic coupling (67)