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In older adults, lifestyle modifications remain a significant challenge [11, 20], and the increasing burden of NCDs further underscores the strategic role of pharmacotherapy as part of a comprehensive strategy of the obesity management

The largest body weight reduction documented for any selective GLP-1R agonist and establishing Semaglutide as the reference compound for studying the maximum efficacy boundary of GLP-1R-mediated central appetite suppression and obesity pharmacology

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