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The modern scientific framework emerged in the early 20th century with Metchnikoff, who proposed that yogurt-derived bacteria could beneficially modulate the gut microbiota and improve health, opening the way for systematic probiotic research and strain isolation from diverse sources, including non-traditional niches such as fish gallbladders (21, 22)

Patients should maintain adequate hydration, particularly during the initial weeks of treatment when gastrointestinal effects are most pronounced

Long-Term Solution: Addresses the underlying issue, offering a more lasting remedy