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In the ATTAIN-1 Phase 3 trial, the most frequently reported adverse events with orforglipron 36 mg versus placebo were nausea (33.7% vs 10.4%), constipation (25.4% vs 9.3%), diarrhea (23.1% vs 9.6%), and vomiting (24.0% vs 4.0%)

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These products are the most abundant fatty acids found in triglycerides, cholesterol esters, wax esters, and phospholipids

[4] Whilst this increase is generally clinically insignificant, some patients may become more aware of their heartbeat, particularly if they are monitoring their health closely during weight loss treatment