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Emerging trends in the nanomedicine applications of functionalized magnetic nanoparticles as novel therapies for acute and chronic diseases

A New Approach for the Prevention and Treatment of Cardiovascular Disorders

Abstract Valproic acid (VPA) is a broad-spectrum antiepileptic drug and is usually well tolerated, but rare serious complications may occur in some patients receiving VPA chronically, including haemorrhagic pancreatitis, bone marrow suppression, VPA-induced hepatotoxicity (VHT) and VPA-induced hyperammonaemic encephalopathy (VHE)

The longitudinal monitoring task is more likely to serve as sensitive secondary or exploratory endpoints, or even primary endpoints, in drug and device clinical trials, particularly for capturing subtle symptom changes and continuous symptom fluctuations, and assessing real-world quality of life [171, 181, 190]