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Abbreviations CMAP: Compound motor action potential CNS: Central nervous system ECM: Cone-extracellular matrix egr-1 gene : Early growth response-1 gene EMG: Electromyography FAK: Focal adhesion kinase GLP: Good laboratory practice HNE: 4-Hydroxynonenal HPLC: High-pressure liquid chromatography JAK-2: Janus kinase 2 LD1: Lethal dose 1 LTB4: Leukotriene B4 MPO: Myeloperoxidase MPTP: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine MUP: Motor unit potential naB2: Nerve growth factor 1-A binding protein-2 NSAIDs: Non-steroid anti-inflammatory drugs SCI: Spinal cord injury TXB2: Thromboxane B2 References Seiwerth S, Rucman R, Turkovic B, Sever M, Klicek R, Radic B, et al

We believe that an enhanced understanding of [] the structural changes within intervertebral disc tissue and inflammatory responses will help identify novel therapeutic targets and enable effective treatment. Within the spine there are numerous chemical messengers released by neurons called neurotransmitters that carry signals and information between cells

For those with neurological symptoms, hydroxocobalamin 1 mg is given on alternate days until no further improvement is observed, as recommended by NICE guidance and the product information