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It was originally developed to explore its potential in treating skin conditions like erythropoietic protoporphyria and vitiligo
[1] [3] These occur because GLP-1 receptor agonists affect the digestive system directly as part of their mechanism of action
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In the landmark STEP 1 trial, patients treated with once-weekly semaglutide achieved an average weight loss of 14.9% of body weight over 68 weeks (Wilding et al., New England Journal of Medicine , 2021)
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