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There has been a long-standing concern that antidepressants may have a role in inducing worsening of depression and the emergence of suicidality in certain patients during the early phases of treatment
Overall, at week 88, participants with 75% or more weight regain after tirzepatide withdrawal reversed cardiometabolic parameters to baseline (week 0) values, the team write, although they note those with up to 50% weight regain still showed improvements in these areas compared with the start of the study
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