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Signaling occurs through two distinct mechanisms: intracellularly via nuclear translocation with SMAD3 and extracellularly after secretion and binding to its receptor, composed of IL18R1 and IL18RAP

The cytosolic enzymes are functional as dimers and since the alpha and mu proteins can form functional heterodimers, the complexity of functional enzymes is greater than the number of individual subunit genes

Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-1: potential role in idiopathic pulmonary fibrosis

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