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The mutation of GIPR Glu 354 to Gln increases GIP affinity, enhances the agonist residence time by 25%, increases cAMP activity, and facilitates the rate of internalization by 2.12.3-fold
Sequential Administration Studies: Another valid approach is to study the effects of one peptide, followed by a proper washout period, and then the administration of the second peptide in the same cohort
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