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2.2% placebo) In a blinded extension for participants with baseline BMI 35, the 12 mg group reached 30.3% weight loss at 104 weeks, with no plateau observed Mazdutide GLORY-1 (Phase 3, published in NEJM, 2025): 610 Chinese adults with obesity or overweight with comorbidities, randomized to 4 mg, 6 mg, or placebo over 48 weeks: 4 mg: 11.0% weight loss 6 mg: 14.0% weight loss (vs
doi: 10.1016/j.jbspin.2025.105904
This is vastly different from anything a probiotic has ever achieved
the presence of IR is associated to higher rates of liver-specific and overall mortality [9, 10]
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