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ii) mitochondrial impairment leading to ROS accumulation

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10.1016/j.lfs.2019.05.030 103 WangW.HuX.XiaZ.LiuZ.ZhongZ.LuZ.et al (2020)

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To overcome these limitations, this review discusses a range of structural modifications, including N-terminal and C-terminal substitutions, fatty acid conjugation, and large molecule fusion technologies, which have collectively contributed to enhanced half-life, increased stability, improved receptor affinity, and retained or augmented bioactivity of GLP-1 analogs

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