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Cytokine Modulation Pro-inflammatory cytokines like TNF-alpha, IL-6, and IL-1beta drive the inflammatory cascade that causes pain, swelling, and tissue damage
Benito J, Lu H, Shi Y, Jacamo R, McQueen T, Konoplev S, Bueso-Ramos C, Zweidler-McKay P, Handisides C, Hart M, Andreeff M , Konopleva M
In that sense, loss-of-function mutations in KEAP1 gene leading to higher NRF2 activation have been identified in several human adenocarcinoma, with lung cancer being the type where this gene is most mutated 34
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