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Similar pathway exhaustion phenomena have been observed in other chronic conditions characterized by persistent oxidative stress [14, 19, 33]

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Our results concluded that i) intracellular GSH is associated with antibiotic susceptibility, ii) extracellular GSH exhibited antibacterial activity regardless of antibiotic susceptibility and resistance, iii) the antibacterial activity of GSH synergistically enhanced susceptibility of conventional antibiotics, and iv) GSH-mediated acidity was partially associated with the antibacterial activity of GSH