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For more information , see the Riboflavin article

Channelling inflammation: gasdermins in physiology and disease

On the other hand, DAM can also exert neuroprotective functions through TREM2 signaling, as evidenced by the finding that TREM2 deficiency exacerbates pathological TDP-43 inclusions, motor dysfunction, and neurodegeneration (Xie et al., 2022)