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7,9 The emergence and expansion of resistant clones are often driven by Darwinian evolutionary principles, whereby treatment selectively eliminates sensitive populations while allowing drug-tolerant persister (DTP) cells or preexisting resistant subclones to dominate
Clinical data support this: subjects receiving glutathione showed a trend toward lower melanin indices in sun-exposed areas
While the nephroprotective effects of SGLT2i were initially derived from secondary endpoints of CV outcome trials (CVOTs), direct confirmation came from dedicated kidney focused trials: CREDENCE (Perkovic et al NEJM 2019| NephJC Summary), DAPA-CKD (Heerspink et al NEJM 2020| NephJC Summary) and finally EMPAKIDNEY (Herrington et al NEJM 2023| NephJC Summary)
Boca Raton, FL: CRC Press (2021)
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