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GLP-1 and its receptor agonists have been shown to reduce endothelial inflammation and oxidative stress, through the activation of nitric oxide production, crucial for maintaining healthy vascular tone and function ( Incretin-based therapies has evidenced a reduced cardiovascular risk in high-risk individuals with type 2 diabetes, independent of the need for additional glucose control
Epigenetic factors, including DNA methylation, histone modifications, and microRNAs, further modulate BCMO1 expression, influenced by diet, inflammation, and stress [22]
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Similar to the transcriptomic changes observed in the hypothalamus, we found that the conjugate prompted transcriptional patterns enriched for functional terms associated with synaptic transmission, including postsynaptic specialization and neuron-to-neuron synapse in the brainstem (Extended Data Fig
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