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Gastrointestinal symptoms that some patients experience while on GLP-1 therapysuch as nausea, reduced appetite, or altered bowel habitsgenerally resolve as the medication clears from the system, typically within 1-2 weeks for short-acting formulations and within 4-8 weeks for long-acting preparations, corresponding to their elimination timelines

Despite literature touting GLP-1s as long-term treatments, prescribers have indicated to Urick that patients often only use the drugs to reach certain weight loss goals and then discontinue treatment once these are accomplished

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Editors Note: This article also appeared in the January/February 2025 issue of Consumer Reports magazine.