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Disrupted HPA axis After a stressful event, the hypothalamus secretes corticotropin-releasing hormone (CRH), which causes the pituitary gland to secrete adrenocorticotropic hormone (ACTH), which in turn causes glucocorticoids (GCs) to be released by the adrenal cortex
International Journal of Endocrinology, 2012, Article ID 456279
Extensive experimental and computational studies have shown that the binding of GSH to GSTs decreases the p K a of the GSH thiol group from around 9 to about 6 in the active site through hydrogen bonding and salt bridges and through the positive electrostatic potential of the G-site 41,42
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